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P62-mediated mitophagy inducer

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  • HY-115576
    P62-mediated mitophagy inducer
    3 Publications Verification

    PMI

    		 p62 Mitophagy Autophagy Neurological Disease Cancer
    P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential .
    <em>P62-mediated</em> <em>mitophagy</em> <em>inducer</em>

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